ncRNA name | CTGF siRNA |
ncRNA Category | siRNA |
Disease name | diabetic retinopathy (DR) |
Species | Rattus norvegicus |
Tissues/Cell_line | retinas; Rat-2 fibroblasts |
Methods | siRNA transfection and injection, immunohistochemistry, qRT-PCR, Western blot |
Expression pattern | associated |
Functional description | Treatment of diabetic rats with CTGF siRNA decreased laminin β1, collagen IVα3 mRNA, and CTGF mRNA and protein but did not affect fibronectin or vascular endothelial growth factor mRNA levels. |
PubMed ID | 22511849 |
Year | 2012 |
Title | Inhibition of connective tissue growth factor by small interfering ribonucleic acid prevents increase in extracellular matrix molecules in a rodent model of diabetic retinopathy. |
Drug-related ncRNA | NO |
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